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aggregation activities antiplatelet :

Anti-platelet aggregation activities of different ...

2015-6-20  MATERIALS AND METHODS: Nephelometery was applied to evaluate anti-platelet aggregation activity of multi-components of A. venetum. Systematic separation components were characterized by HPLC analysis method, and in vitro screening active components by anti-platelet aggregation study.

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Antiplatelet aggregation activity of diterpene alkaloids ...

2002-8-2  It concentration-dependently inhibited platelet aggregation induced not only by PAF, but also by ADP and arachidonic acid, showing a non-selective antiplatelet aggregation action. And the inhibition of arachidonic acid-induced platelet aggregation was as potent as that induced by aspirin, suggesting that the antiplatelet activity pattern of atisine-type alkaloids might be affected by changes in some

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Antiplatelet aggregation activity of diterpene alkaloids ...

2002-8-2  suggesting a non-selective antiplatelet aggregation action. The inhibitory effect of spiramine C1 on arachidonic acid was as potent as that of aspirin. Primary studies of the structure-activity relationships for inhibition of PAF-induced aggregation showed that the oxygen substitution at

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Synthesis, Antiplatelet Aggregation Activity Evaluation ...

2016-2-9  The results of the antiplatelet aggregation activity evaluation and analysis of the self‐organizing molecular field analysis models through shape and electrostatic grids may provide a basis for the development of new and potent antiplatelet agents.

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New Copper Compounds with Antiplatelet Aggregation

Compound (C2) exhibited the strongest antiplatelet aggregation activity. Conclusion: Schiff base copper(II) complexes, which are attracting increasing interest, could represent a new approach to treat thrombosis by blocking the activity of PolyP with a potential anticoagulant activity and, most importantly, demonstrating no adverse bleeding events.

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Synthesis and Antiplatelet Aggregation Activities in Vitro ...

2014-9-23  in vitro Evaluation of Anti-Platelet Aggregation Activities The in vitro activities of the nineteen compounds were tested and assessed by using the method of Born test [ 10, 11 ]. Rabbit plasma used to measure the derivatives anti-platelet aggregation activity.

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Triterpenoids with antiplatelet aggregation activity from ...

The antiplatelet aggregation of all compounds were evaluated against ADP induced rat platelet aggregation in vitro, and five compounds exhibited moderate inhibitory effects with IC 50 values ranging from 22.4 to 32.8 μM.

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Triterpenoids with Antiplatelet Aggregation Activity from ...

The structures of the new compounds were established by a combination of chemical and spectroscopic methods, including HRESIMS, 1 H-NMR, 13 C-NMR, 1 H- 1 H COSY, HSQC, HMBC, and NOESY. Additionally, the biological activity of compounds 1 - 15 against adenosine diphosphate-induced platelet aggregation in rabbit plasma was determined.

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Synthesis, Antiplatelet Aggregation Activity Evaluation ...

Synthesis, Antiplatelet Aggregation Activity Evaluation and 3D‐QSAR of a Series of Novel 6‐Alkylamino(Alkoxyl)‐2‐Propylthio‐8‐Azapurine Nucleosides H. G. Du College of Science, Beijing University of Chemical Technology, 15 Beisanhuan East Road, Chaoyang District, Beijing, 100029 China

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Anti-inflammatory, Antiplatelet Aggregation, and ...

2020-8-14  analysis. The biological activities of all isolates were evaluated using four types of bioassays including cytotoxicity, anti-inflammatory, antiplatelet aggregation, and antiangiogenesis activities. Compounds 4 and 6 showed potent anti-inflammatory activity, compound 2 possessed potent antiplatelet aggregation and antiangiogenesis

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In Vitro Antiplatelet Aggregation Activity of Aqueous and ...

2020-6-30  platelet activation and aggregation. In this study, antiplatelet aggregation activities of aqueous and alcoholic extracts of AILE were performed at the concentration of 200, 400 and 800 µg/ml respectively. The effect of extracts at different concentrations were measured and compared with the standard drug aspirin (Table 1).

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Antiplatelet Aggregation Activity of a Fraction Isolated ...

ABSTRACT A fraction isolated from crude aqueous extract of Galega officinalis L. and purified by column chromatography inhibit platelet aggregation in platelet-rich plasma. The active fraction of the extract, molecular weight of 100–140 kDa, appeared to be polysaccharide-protein complex. Aggregation of platelets initiated by 25 μM ADP was inhibited 50 percent by 11.2 μg/ml of the fraction.

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In Vitro Antiplatelet Aggregation Activity of Centella ...

2017-7-5  naturally derived antiplatelet aggregation with fewer side effects. From in vitro study, Centella asiatica (CA) has been known to have some pharmacodynamic activities such as wounds healing3, anti peptic ulcer4, mental disorders, antiviral, fungicidal, antibacterial and many others5. CA

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Synthesis, Antiplatelet Aggregation Activity Evaluation ...

Synthesis, Antiplatelet Aggregation Activity Evaluation and 3D‐QSAR of a Series of Novel 6‐Alkylamino(Alkoxyl)‐2‐Propylthio‐8‐Azapurine Nucleosides H. G. Du College of Science, Beijing University of Chemical Technology, 15 Beisanhuan East Road, Chaoyang District, Beijing, 100029 China

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Design, Synthesis, and In Vitro Antiplatelet Aggregation ...

In order to discover new compounds with antiplatelet aggregation activities, some ferulic acid (FA) derivatives were designed and synthesized. The in vitro antiplatelet aggregation activities of these compounds were assessed by turbidimetric test. The results showed that the target compound 7f had potent antiplatelet aggregation activity with its IC50 27.6#x2009;#x3BC;mol/L ...

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Antiplatelet aggregation and antithrombotic benefits of ...

2019-1-9  Particularly, compounds 10 and 24 inhibited ADP-induced platelet aggregation and delayed FeCl 3-induced thrombus in zebrafish. Furthermore, interactions between compounds 10 and 24 with two ADP receptors P2Y 1 and P2Y 12 , serving as the target for key regulators of antiplatelet

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Synthesis and in vitro activities on anti-platelet ...

2019-6-10  Cardiovascular diseases are the most frequent cause of morbidity and mortality worldwide. In order to discover novel compounds with anti-platelet aggregation activities, a series of novel 4-methoxy-1,3-phthalamidesamides (1a–1i) and a series of novel 4-methoxy-1,3-benzenedisulfon-amides (2a–2i) were synthesized and their anti-platelet aggregation activities were evaluated by the ...

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Anti-inflammatory, Antiplatelet Aggregation, and ...

2020-8-14  analysis. The biological activities of all isolates were evaluated using four types of bioassays including cytotoxicity, anti-inflammatory, antiplatelet aggregation, and antiangiogenesis activities. Compounds 4 and 6 showed potent anti-inflammatory activity, compound 2 possessed potent antiplatelet aggregation and antiangiogenesis

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Synthesis and in vitro activities on anti-platelet ...

2018-6-26  A series of 4-methoxyisophthalamides (1d–1w) were designed and synthesized and their chemical structures were confirmed by IR, MS, 1H-NMR, and 13C-NMR. The in vitro on anti-platelet aggregation activities of these compounds were assessed by using Born method. Compounds with higher activities were selected to continue research via Cell Counting Kit-8 (CCK-8) assays of their

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争论:折耳根含马兜铃内酰胺,到底致癌不? - 知乎

2019-8-19  2. Qu, W., et al. (2011) Alkaloids from Houttuynia cordata and Their Antiplatelet Aggregation Activities. Chinese Journal of Natural Medicines. 相关文章: 重磅研究:亚洲大批肝癌和马兜铃酸有关,有毒的中草药千万别乱吃!西药也有毒,凭啥盯着马兜铃酸不放?

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In Vitro Antiplatelet Aggregation Activity of Aqueous and ...

2020-6-30  platelet activation and aggregation. In this study, antiplatelet aggregation activities of aqueous and alcoholic extracts of AILE were performed at the concentration of 200, 400 and 800 µg/ml respectively. The effect of extracts at different concentrations were measured and compared with the standard drug aspirin (Table 1).

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争论:折耳根含马兜铃内酰胺,到底致癌不? - 知乎

2019-8-19  2. Qu, W., et al. (2011) Alkaloids from Houttuynia cordata and Their Antiplatelet Aggregation Activities. Chinese Journal of Natural Medicines. 相关文章: 重磅研究:亚洲大批肝癌和马兜铃酸有关,有毒的中草药千万别乱吃!西药也有毒,凭啥盯着马兜铃酸不放?

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Anti-inflammatory, Antiplatelet Aggregation, and ...

2020-8-14  analysis. The biological activities of all isolates were evaluated using four types of bioassays including cytotoxicity, anti-inflammatory, antiplatelet aggregation, and antiangiogenesis activities. Compounds 4 and 6 showed potent anti-inflammatory activity, compound 2 possessed potent antiplatelet aggregation and antiangiogenesis

Read More
In Vitro Antiplatelet Aggregation Activity of Centella ...

2017-7-5  naturally derived antiplatelet aggregation with fewer side effects. From in vitro study, Centella asiatica (CA) has been known to have some pharmacodynamic activities such as wounds healing3, anti peptic ulcer4, mental disorders, antiviral, fungicidal, antibacterial and many others5. CA

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Anti-Platelet Aggregation and Anti-Cyclooxygenase ...

Coffee is rich in caffeine (CF), chlorogenic acid (CGA) and phenolics. Differing types of coffee beverages and brewing procedures may result in differences in total phenolic contents (TPC) and biological activities. Inflammation and increases of platelet activation and aggregation can lead to thrombosis. We focused on determining the chemical composition, antioxidant activity and inhibitory ...

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Antiplatelet aggregation and antithrombotic benefits of ...

2019-1-9  Particularly, compounds 10 and 24 inhibited ADP-induced platelet aggregation and delayed FeCl 3-induced thrombus in zebrafish. Furthermore, interactions between compounds 10 and 24 with two ADP receptors P2Y 1 and P2Y 12 , serving as the target for key regulators of antiplatelet

Read More
Antiplatelet Aggregation Activity of a Fraction Isolated ...

ABSTRACT A fraction isolated from crude aqueous extract of Galega officinalis L. and purified by column chromatography inhibit platelet aggregation in platelet-rich plasma. The active fraction of the extract, molecular weight of 100–140 kDa, appeared to be polysaccharide-protein complex. Aggregation of platelets initiated by 25 μM ADP was inhibited 50 percent by 11.2 μg/ml of the fraction.

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Antiplatelet, Antithrombotic, and Fibrinolytic Activities ...

Hence, the C. xanthocarpa extract with a combination of antiplatelet aggregation, antithrombotic, and fibrinolytic activities may be effective in preventing thrombus formation through several pathways. Saponins are widely distributed in plants and have many biological activities, such as antiplatelet activity [

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Antiplatelet aggregation and antimicrobial activities of ...

The methanol extract was analysed for antiplatelet aggregation assay. It was found that highest per cent activity was found in freeze-dried pulp (32.50%), rind (28.33%) and seed (10.13%). The bael plant part extracts shown to be potential antibacterial and antiplatelet aggregation activities.

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Anti-Platelet Aggregation Activities of Shallot andGarlic ...

Methanol extracts of freeze-dried garlic and shallot had antiplatelet aggregation activity (D50) of 0.08 dan 0.30 mg/ml, respectively. The oven dried products obtained under optimal conditions (70°C, 10 hrs) had antiplatelet aggregation activities of 0.31 and 0.70 mg/mg, respectively.

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